The Key Role of Cryopreservation in IVF
Speaking next, Laura Rienzi, PhD, of Genera Centres for Reproductive Medicine, Italy, discussed the key role of cryopreservation in IVF. She called vitrification a “game-changer,” as it has improved the quality of IVF care in many ways.
She explained that vitrification can enhance the cumulative live birth rate by offering the opportunity for more than one pregnancy from a single IVF cycle. According to her research, this has significantly increased the rate of single embryo transfers and thereby reduced the rate of multiple pregnancies.1
Vitrification also enables cycle segmentation for patients who experience ovarian hyperstimulation syndrome (OHSS) and need to delay their embryo transfer. Additionally, it can give the lab more time to evaluate the embryo cohort by performing PGT.
Fertility preservation has been hugely impacted by vitrification, where women can now pause their biological clocks for medical or non-medical reasons, and this is great news. The gamete donation industry has also been positively impacted, as oocyte vitrification enables gamete donation across borders.1
While the benefits of vitrification are clear, embryologist skill is crucial to its success. Although survival rates post-vitrification and warming are very high from 2PNs to blastocysts, they vary significantly across operators.1 Vitrification is inherently inconsistent due to its manual nature.
Clearly, there is room for improvement. Standardizing vitrification procedures and protocols across the embryology field, as well as adopting automation where possible, may improve the precision of timings, volumes, and manipulations.
Watch the recorded session here to find out how vitrification can be applied to all stages of development with high efficiency: