Our UK and Ireland Senior Genetic Counsellor, Jennifer Sloan, MSc, CCRP, helps to ‘demystify’ PGT-M analysis via Karyomapping by explaining the optimal design approach for various inheritance patterns, commonly referred inherited disorders and genetic counselor review, family references and alternative designs and the evaluation of de novo approach and limitations. The presentation is followed by a panel session with Jennifer joined by Tony Gordon, PhD, and Leoni Xanthopoulou, PhD.