David Miller

David Miller PhD

Reader in Molecular Andrology, University of Leeds 

Since completing his PhD in dental biochemistry in 1982, David has worked in academia for over 35 years on a range of models from slime moulds (1982-84) to brine shrimps (1985-89)  before settling on basic Andrology and on sperm DNA and RNA and its packaging in the sperm nucleus (1989-2020). He retired in Jan 2020 from the University of Leeds where he retains his title as Reader in Molecular Andrology.  

David’s most recent accomplishment was the HAB Select study, looking at whether embryos fertilised with sperm ‘captured’ by hyaluronic acid  (HA) and used in ICSI procedures were better at going on to successful live births and reducing miscarriage rates than sperm selected by the embryologist alone. Alongside this was a mechanistic study aimed at finding out what was different about HA-selected sperm that may explain the clinical effects seen in the trial. In the end, the use of HA-selected sperm in the blinded and randomised clinical trial did not significantly increase live birth rates, but did, paradoxically, significantly reduce miscarriage rates.

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