One step immobilization and selection of mature sperm for ICSI without the use of PVP

SpermSlow™ is a semi viscous medium containing Hyaluronan for slowing down the movement and for the selection of an individual sperm with enhanced genetic and developmental integrity1.

Significantly higher embryo development rate and better embryo quality found in sperm with Hyaluronan receptors.

Key Features

  • Replaces PVP in the sperm selection process
  • Significantly higher embryos development rate with the use of SpermSlow compared to PVP1
  • Better embryo quality1
  • Lower rates of chromosomal aneuploidies in Hyaluronan-selected sperm2, 3
  • Lower rates of DNA fragmentation in Hyaluronan-selected sperm2, 3
  • Lower rates of early miscarriage3


This product is available for sale in Europe, Australia, as well as selected countries in the rest of the world.


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Watch the video to see how SpermSlow helps you select the best sperm for ICSI

  • Select mature sperm for ICSI using nature’s own biomarker for sperm quality

  • The in vitro selection of sperm is critical for ICSI

  • Visual selection alone cannot identify sperm with compromised development, nuclear, and cytoplasmic competence

Sperm selection with SpermSlow improves implantation rates compared to PVP4


Retrospective observational study of couples treated with ICSI after sperm selection with either SpermSlow (N=293; 331 treatments performed) or PVP (N=86; 97 treatments performed); *p-value <0.05

Reduction in DNA fragmentation rate after selection with SpermSlow5


Prospective study of 20 men in a private ART center in Italy; *p-value <0.001

Sperm selection for ICSI by HA binding mimics the natural selection of sperm with high DNA integrity by the zona pellucida.6,7
Lack of zona pellucida binding is a major cause of IVF fertilization failure7

Order Codes

Reference Description Size Shelf Life Guarantee*
10944000 SpermSlow 4×0.1 ml Minimum 12 weeks

*Minimum time to expiry (from date of shipment from Denmark)

  • Adenine
  • Alanine
  • Arginine
  • Ascorbic acid
  • Asparagine
  • Aspartic Acid
  • Calcium Chloride
  • Calcium Lactate
  • Calcium pantothenate
  • Cholesterol
  • Choline Chloride
  • Cysteine
  • Cytosine
  • D-Biotin
  • Disodium Hydrogen Phosphate
  • Folic Acid
  • Gentamicin sulphate
  • Glutamic Acid
  • Glucose
  • Glutamine
  • Glycine
  • Guanine
  • Histidine
  • Human Albumin Solution
  • Hyaluronate
  • Hydrochlorid Acid
  • Hypotaurine
  • Inositol
  • Isoleucine
  • Leucine
  • L-Malic acid
  • Lysine
  • Magnesium Sulfate
  • Milli RX Water
  • Methionine
  • Phenylalanine
  • Potassium Chloride
  • Potassium Phosphate
  • Proline
  • Pyridoxine
  • Riboflavin
  • Recombinant Human Insulin
  • Serine
  • Sodium acetate
  • Sodium Bicarbonate
  • Sodium Chloride
  • Sodium phosphate
  • Sodium Pyruvate
  • Sodium citrate
  • Taurine
  • Thiamine
  • Threonine
  • Thymine
  • Tryptophan
  • Tyrosine
  • Uracile
  • Valine
  • Vitamin B12
  • Sterility tested (Ph. Eur., USP)
  • Endotoxin tested ≤ 0.1 EU/ml (Ph. Eur., USP)
  • Sperm Survival tested
  • 1. Parmigiani L. et al., (2010). Fertil Steril. 93. No 2
  • 2. Jakab. A. et al.,(2005). Fertil Steril. 84, No 6.
  • 3. Worrilow. K et al., (2012) Hum Rep. 28. No 2
  • 4. Parmegiani L, et al. “Physiologic ICSI”: Hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality. Fertility and Sterility. 2010;93:598–604
  • 5. Parmegiani L, et al. Efficiency of hyaluronic acid (HA) sperm selection. J Assist Reprod Genet. 2010;27:13–16
  • 6. Yagci A, et al. Spermatozoa bound to solid state hyaluronic acid show chromatin structure with high DNA chain integrity: an acridine orange fluorescence study. Journal of Andrology. 2010;31:566–572
  • 7. Liu DY, Baker HW. Human sperm bound to the zona pellucida have normal nuclear chromatin as assessed by acridine orange fluorescence. Hum Reprod. 2007;22:1597–1602